TB-500

TB-500

$130.00

Thymosin β4 Active Fragment (17–23) · Acetylated Heptapeptide

TB-500 is a synthetic 7-amino-acid peptide fragment corresponding to the primary functional domain (residues 17–23) of the naturally occurring peptide Thymosin β4 (Tβ4). Modified with an N-terminal acetyl group (Ac-LKKTETQ-OH), TB-500 represents the central actin-binding motif responsible for regulating cytoskeletal assembly. Preclinical research evaluates its role in G-actin sequestration, actin polymerization kinetics (G-actin→F-actin dynamics), cell migration, and endothelial tube formation. Literature extensively documents its involvement in tissue repair pathways, dermal wound healing, cardiac remodeling models, and anti-inflammatory signaling cascades, as well as analytical detection methods in sports anti-doping assays.

Supplied at 10mg.

SKU: TB500-10MG Categories: ,

Description

Overview

TB-500 is a synthetic heptapeptide derivative comprising amino acids 17 to 23 of the naturally occurring 43-amino-acid protein Thymosin β-4 (Tβ4). Featuring an N-terminal acetylation (Ac-LKKTETQ), this short fragment isolates the active region responsible for binding monomeric actin.

In laboratory models, TB-500 regulates cytoskeletal dynamics, cell migration, extracellular matrix reorganization, and localized angiogenesis without requiring the full-length protein sequence.

Key Technical Specifications

Sequence Ac-LKKTETQ-OH
(N-Acetyl-Leu-Lys-Lys-Thr-Glu-Thr-Gln)
Molecular Formula C₃₈H₆₈N₁₀O₁₄
Molecular Weight ~889.02 g/mol
CAS Number 885340-08-9
Solubility Bacteriostatic Water / Sterile Water
Primary Class Actin-Sequestration & Cytoskeletal Modulator

Biochemical Architecture & Mechanisms

1. G-Actin Sequestration & Cytoskeletal Assembly

TB-500 interacts directly with cellular structural components:

  • Actin Dynamics: Binds monomeric G-actin to maintain a pool of precursors required for microfilament assembly (F-actin), directly controlling cellular motility.
  • Cellular Migration: Promotes directional movement of dermal fibroblasts, keratinocytes, and endothelial cells toward tissue regeneration zones.

2. Angiogenesis & Extracellular Matrix Repair

Supports microvascular structure and tissue remodeling:

  • Vascular Tube Formation: Stimulates endothelial cell differentiation, facilitating new capillary outgrowth in damaged tissue models.
  • Matrix Regulation: Modulates collagen deposition and matrix metalloproteinase pathways to minimize fibrotic scar tissue formation.

Analytical & Detection Standard: Due to its distinct small-molecule structure, TB-500 is extensively utilized in research environments as a reference standard for developing mass spectrometry (LC-MS/MS) anti-doping detection methodologies.

For laboratory research, educational, and analytical reference only. Strictly not for human or veterinary use.

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