BPC-157

$70.00

Pentadecapeptide · Gastric Body Protection Compound Fragment

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid pentadecapeptide modeled after a biological fragment of human gastric juice protein. Manufactured via solid-phase peptide synthesis (SPPS), BPC-157 exhibits high stability across gastric acid environments and enzymatic degradation profiles. Preclinical research extensively characterizes its involvement in gastrointestinal mucosal integrity, cellular migration, and tissue regeneration mechanisms. Biological studies focus on its upregulation of vascular endothelial growth factor (VEGF), modulation of nitric oxide (NO) signaling pathways, activation of focal adhesion kinase (FAK) and paxillin in fibroblast outgrowth, and tendon-to-bone healing kinetics across in vivo research models.

Supplied at 10mg.

Description

Overview

BPC-157 is a synthetic 15-amino-acid pentadecapeptide derived from a functional fragment of biological human gastric juice protein. Synthesized on solid phase support and lyophilized for research application, BPC-157 retains stability across diverse pH environments.

In preclinical studies, BPC-157 is evaluated for its systemic cytoprotective properties, specifically its role in accelerating soft tissue healing, promoting fibroblast growth, modulating angiogenesis, and protecting mucosal lining structures.

Key Technical Specifications

Sequence	`GEPPPGKPADDAGLV`
Molecular Formula	C₆₂H₉₈N₁₆O₂₂
Molecular Weight	~1419.55 g/mol
CAS Number	137525-51-0
In Vivo Half-Life	~7.9–30 min (rodent models)
Solubility	Bacteriostatic Water / Sterile Water
Primary Class	Cytoprotective Pentadecapeptide

Biochemical Architecture & Mechanisms

1. Angiogenic Pathways & Vascular Repair

BPC-157 supports local tissue restoration by facilitating pro-angiogenic cascades:

VEGF Activation: Promotes upregulation of vascular endothelial growth factor (VEGF) to form new microvascular networks in damaged tissue.
Endothelial Sprouting: Accelerates blood vessel formation, ensuring oxygen and nutrient delivery to repair zones.

2. Cellular Migration & Connective Tissue Synthesis

Targeted interactions with cell structural machinery enhance tissue remodeling:

FAK-Paxillin Axis: Phosphorylates focal adhesion kinase (FAK) and paxillin proteins to accelerate cell motility and migration in fibroblasts.
Extracellular Matrix Support: Stimulates collagen production in tendon, ligament, and muscle research models.

Nitric Oxide Signaling: BPC-157 displays a protective, counter-regulatory effect on nitric oxide synthase (NOS) pathways, helping balance systemic vasodilation and protecting mucosal barrier integrity in gastrointestinal models.

For laboratory research, educational, and analytical reference only. Strictly not for human or veterinary use.